Spellcheck has pioneered a new form of DNA editing that checks for somatic mutations before fixing them. This is a surgically precise approach, that only edits when needed. A “spellchecker” for the genome.
As we age, our genome is constantly being damaged by exogenous and endogenous sources.
Occasionally errors are missed and incorporated into the DNA in the form of mutations, structural variations, epigenetic drift, and other types of information loss.
Matter Bio will intervene at 4 critical junctures of information loss
Immune therapies face a triple limitation:
Loki’s immune-AWAKE™ bacterial platform overcomes these challenges and enable visualization and eradication of solid tumors and metastases
Selective infection + destruction of tumor cells is enabled by 3 key innovations
Single-cell sequencing to detect point mutations orders of magnitude cheaper, better, and faster than competing methods
SMM-sequencing uses rolling circle–based linear amplification (RCA) to produce single-stranded DNA molecules composed of multiple concatemerized copies of equally represented DNA strands of each particular DNA fragment.
Because all these copies are independent replicas of the original DNA fragment, potential errors of amplification remain unique for each copy and do not propagate further. Copies of opposite strands are in an end-to-end orientation and separated by common spacers used as polymerase chain reaction (PCR) priming sites during the second step of the process when concatemerized copies are individually amplified and converted into a sequencing library. DOI: 10.1126/sciadv.abm3259